Glifosato como disruptor endocrino: una revisión bibliográfica.

Ching Patiño, Laura Valentina; Castañeda Palacios, Laura Catalina

Publicación:
Glifosato como disruptor endocrino: una revisión bibliográfica.

dc.contributor.advisor	Cifuentes Prieto, Patricia
dc.contributor.author	Ching Patiño, Laura Valentina
dc.contributor.author	Castañeda Palacios, Laura Catalina
dc.date.accessioned	2025-11-12T16:36:15Z
dc.date.issued	2025
dc.description.abstract	El glifosato es uno de los herbicidas más efectivos utilizados para el control y la erradicación de malezas, sin embargo, se encuentra en discusión su rol como potencial disruptor endocrino en el ser humano. A partir de una revisión bibliográfica para poder identificar los posibles efectos endocrinos del glifosato en publicaciones referentes a las posibles consecuencias hormonales por exposición al herbicida, se determinó que los mecanismos de acción a través de los cuales actúa, son la desregulación en las vías del ciclo celular y reparación del ADN, inducción de apoptosis, hiperplasia, necrosis, proliferación celular, alteraciones genéticas que afectan los niveles de expresión hormonal, aumento del estrés oxidativo e inhibición de enzimas involucradas en el proceso de síntesis hormonal. Aunque la exposición podría parecer mayor en la población que trabaja directamente con este compuesto existe un traslado de la contaminación del campo al contexto doméstico a través de los elementos y medidas de protección personal implementadas por los trabajadores. La búsqueda de información se realizó en las bases de datos como Scopus, PubMed y NCBI. Se utilizaron términos como “glyphosate”, “exposure” y “endocrine disruptor” para poder direccionar la búsqueda. Finalmente, se encontró que el glifosato tiene la capacidad de interferir en el equilibrio hormonal principalmente de los estrógenos, andrógenos y hormonas tiroideas, en consecuencia, los efectos endocrinos más frecuentemente hallados en la literatura son alteraciones en la fertilidad, el desarrollo sexual y el metabolismo, sugiriendo así posibles repercusiones en el desarrollo y crecimiento desde el embarazo.
dc.description.degreelevel	Pregrado
dc.description.degreename	Bacteriólogo(a) y Laboratorista Clínico
dc.description.tableofcontents	TABLA DE CONTENIDO 5 ÍNDICE DE FIGURAS ÍNDICE DE TABLAS 1. RESUMEN 6 2. INTRODUCCIÓN 7 2.1. Objetivo general 7 2.2. Objetivos específicos 7 3. ANTECEDENTES 10 4. MARCO REFERENCIAL 11 5. DISEÑO METODOLÓGICO 22 5.1. Universo, población, muestra 5.2. Hipótesis, variables, indicadores. 5.3. Técnicas y procedimientos. 6. RESULTADOS 22 7. DISCUSIÓN 29 8. CONCLUSIONES 36 9. REFERENCIAS BIBLIOGRÁFICAS 36
dc.format.extent	42p.
dc.format.mimetype	application/pdf
dc.identifier.uri	https://repositorio.universidadmayor.edu.co/handle/unicolmayor/7261
dc.language.iso	spa
dc.publisher	Universidad Colegio Mayor de Cundinamarca
dc.publisher.faculty	Facultad de Ciencias de la Salud
dc.publisher.place	Bogota
dc.publisher.program	Bacteriología y Laboratorio Clínico
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dc.rights.license	Atribución-NoComercial-CompartirIgual 4.0 Internacional (CC BY-NC-SA 4.0)
dc.rights.uri	https://creativecommons.org/licenses/by-nc-sa/4.0/
dc.subject.proposal	Glifosato,
dc.subject.proposal	Disrupción endocrina
dc.subject.proposal	Hormonas
dc.subject.proposal	Mecanismos de acción
dc.subject.proposal	Exposición
dc.title	Glifosato como disruptor endocrino: una revisión bibliográfica.
dc.type	Trabajo de grado - Pregrado
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dc.type.driver	info:eu-repo/semantics/bachelorThesis
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dc.type.version	info:eu-repo/semantics/publishedVersion
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