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Niveles de autoanticuerpos anti-peptidos carbamilados y citrulinados y su relación con índices de actividad clínica reumática en pacientes con artritis reumatoide temprana y familiares en primer grado de consanguinidad de pacientes con artritis reumatoide, oriundos de Colombia

dc.contributor.advisorRomero Sánchez, María Consuelo
dc.contributor.advisorChila Moreno, Leidy Lorena
dc.contributor.advisorMuñoz Henao, Julián Esteban
dc.contributor.authorRamos Casallas, Manuel Alejandro
dc.date.accessioned2022-03-09T16:33:00Z
dc.date.available2022-03-09T16:33:00Z
dc.date.issued2018-05
dc.identifier.urihttps://repositorio.universidadmayor.edu.co/handle/unicolmayor/4792
dc.description.abstractLa Artritis Reumatoide (AR) es una enfermedad autoinmune sistémica caracterizada por un estado de inflamación crónica y deterioro progresivo de las articulaciones. Su diagnóstico se basa en una serie de criterios clínicos y pruebas de laboratorio. Este último ítem abarca la detección del Factor Reumatoide (FR) y/o los autoanticuerpos anti-proteínas citrulinadas (anti-CCP), asociados a la actividad de la enfermedad y al pronóstico de la misma. Sin embargo, existen grupos de pacientes con elevado daño articular y niveles indetectables de FR y/o autoautoanticuerpos anti-CCP, dificultando el diagnóstico y las opciones terapéuticas. De forma reciente se descubrieron los autoanticuerpos anti-proteínas carbamiladas (anti-CarP) asociados a esta enfermedad, los cuales permitirían tipificar la AR en estos grupos de pacientes e individuos con condiciones de riesgo, además de poder predecir el desenlace articular. De esta manera se facilitaría el diagnóstico, así como en el tratamiento y el pronóstico. En este estudio se midieron los niveles de autoautoanticuerpos anti-CCP. Así mismo, se midieron los niveles de autoanticuerpos frente al péptido carbamilado de fibrinógeno (empleando el péptido nativo como control), en pacientes con artritis reumatoide temprana y familiares en primer grado de consanguinidad, para establecer su asociación frente al daño reumatológico y periodontal. Los resultados resaltan la asociación entre el número de articulaciones dolorosas e inflamadas y el daño periodontal con la presencia de los anticuerpos anti-péptido de fibrinógeno carbamilado en el grupo de familiares en primer grado de consanguinidad. No hubo asociación entre estos autoanticuerpos y los autoautoanticuerpos anti-CCP en los pacientes con artritis reumatoide temprana. Como hallazgo adicional, se observó que los dos grupos de estudio presentan autoanticuerpos contra el péptido nativo de fibrinógeno. En conclusión, la presencia de autoanticuerpos contra péptidos/proteínas carbamiladas están presentes en la población colombiana con artritis reumatoide temprana y familiares en primer grado de consanguinidad; asociados a manifestaciones de daño articular y periodontal. Además, la presencia de autoanticuerpos frente al péptido de fibrinógeno nativo puede ser un indicio de desarrollo de la enfermedad.spa
dc.description.tableofcontentsTABLA DE CONTENIDO RESUMEN EJECUTIVO 11 INTRODUCCIÓN 13 1. OBJETIVOS 15 1.1. OBJETIVO PRINCIPAL (GENERAL )15 1.2. OBJETIVOS SECUNDARIOS (ESPECÍFICOS)15 2. ANTECEDENTES 17 3. MARCO TEÓRICO 24 3.1. DEFINICIÓN DE ARTRITIS REUMATOIDE 24 3.2. MANIFESTACIONES CLÍNICAS 27 3.3. FACTORES DE RIESGO 28 3.4. EPIDEMIOLOGÍA DE LA ENFERMEDAD EN COLOMBIA. 34 3.5. DIAGNÓSTICO 35 4. METODOLOGÍA 44 4.1. TIPO DE INVESTIGACIÓN 44 4.2. POBLACIÓN 44 4.3. MUESTRA 44 4.4. SELECCIÓN DE LA MUESTRA 44 4.5. CRITERIOS DE INCLUSIÓN 45 4.6. CRITERIOS DE EXCLUSIÓN 45 4.7. HIPÓTESIS 47 4.8. TÉCNICAS Y PROCEDIMIENTOS 48 4.9. ANÁLISIS ESTADÍSTICO 51 5. RESULTADOS 52 6. DISCUSIÓN 86 7. CONCLUSIONES 91 8. REFERENCIAS 92 9. ANEXOS 116 9.1. FORMATO DE CRITERIOS DE EXCLUSION 116 9.2. FORMATO DE RECOLECCION DE DATOS PACIENTES CON AR Y FAMILIARES: 117spa
dc.format.extent117p.spa
dc.format.mimetypeapplication/pdfspa
dc.language.isospaspa
dc.publisherUniversidad Colegio Mayor de Cundinamarcaspa
dc.rightsDerechos Reservados - Universidad Colegio Mayor de Cundinamarca, 2018spa
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/spa
dc.titleNiveles de autoanticuerpos anti-peptidos carbamilados y citrulinados y su relación con índices de actividad clínica reumática en pacientes con artritis reumatoide temprana y familiares en primer grado de consanguinidad de pacientes con artritis reumatoide, oriundos de Colombiaspa
dc.typeTrabajo de grado - Pregradospa
dc.description.degreelevelPregradospa
dc.description.degreenameBacteriólogo(a) y Laboratorista Clínicospa
dc.identifier.barcode58418
dc.publisher.facultyFacultad de Ciencias de la Saludspa
dc.publisher.placeBogotá D.Cspa
dc.publisher.programBacteriología y Laboratorio Clínicospa
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dc.rights.accessrightsinfo:eu-repo/semantics/closedAccessspa
dc.rights.creativecommonsAtribución-NoComercial-CompartirIgual 4.0 Internacional (CC BY-NC-SA 4.0)spa
dc.subject.lembEnfermedad Autoinmune
dc.subject.lembAutoautoanticuerpos
dc.subject.proposalAnticuerposspa
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Derechos Reservados - Universidad Colegio Mayor de Cundinamarca, 2018
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