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Asociación entre mutaciones genómicas y susceptibilidad al desarrollo de lepra: Revisión sistemática y metaanálisis

dc.contributor.advisorChavarro Portillo, Bibiana
dc.contributor.advisorGuerrero Guerrero, Martha Inírida
dc.contributor.authorContreras Martínez, Laura Katherín
dc.date.accessioned2024-09-19T17:23:35Z
dc.date.available2024-09-19T17:23:35Z
dc.date.issued2024
dc.identifier.urihttps://repositorio.universidadmayor.edu.co/handle/unicolmayor/7054
dc.description.abstractLa lepra es una Enfermedad Tropical Desatendida y una neuropatía periférica no traumática, causada por M. leprae y M. lepromatosis. La respuesta inmune innata del huésped, controlada por varios genes, juega un papel importante en la determinación de la susceptibilidad a la lepra incluso antes de la infección inicial con el patógeno. Estas variantes se han observado en poblaciones de diferentes zonas endémicas a nivel mundial.spa
dc.description.tableofcontentsTabla de Contenido 1. INTRODUCCIÓN 12 2. MARCO TEORICO 14 2.1 Enfermedad de Hansen 14 2.2. Agente Causal de la lepra 15 2.3. Epidemiología de la lepra 16 2.4. Características clínicas de la lepra 17 2.5. Inmunología de la Lepra 18 2.5.1. Inmunidad innata 19 2.5.1.1. Acción de los Macrófagos 19 2.5.1.2. Células Dendríticas 20 2.5.2. Inmunidad Adaptativa 20 2.5.2.1. Linfocitos B 20 2.5.2.2. Linfocitos T 20 2.6. Marcadores genéticos en el hospedero 21 2.6.1. El Complejo mayor de histocompatibilidad (HLA) 21 2.6.2. Factor de necrosis tumoral (TNF) 22 2.6.3. Receptores tipo TOLL (TLR) 22 2.6.4. El dominio de oligomerización por unión de nucleótidos que contienen proteína dos (NOD2) 22 2.6.5. Interluquina 10 23 3. OBJETIVOS 24 3.1 Objetivo General 24 3.2 Objetivos específicos 24 4. MATERIALES Y MÉTODOS 25 4.1. Diseño del estudio 25 4.2. Búsqueda de las publicaciones 25 4.2.1. Términos clave 25 4.2.2. Criterios de inclusión y exclusión 26 4.3. Generación de base de datos 26 4.4. Análisis estadístico 26 4.5. Consideraciones éticas 27 5. RESULTADOS 28 5.1. Descripción de estudios incluidos 28 5.2. Datos demográficos de los estudios analizados. 32 5.2.1. Distribución geográfica de los estudios analizados 32 5.3. Análisis de mutaciones de susceptibilidad o resistencia a Lepra 33 5.3.1. Mutaciones en el gen de TNF 33 5.3.2. Mutaciones presentes en el gen IL-10. 34 5.3.3. Mutaciones presentes en el gen TLR1, TLR2, TLR4 y NOD2 en los casos y controles en los estudios analizados. 35 5.3.3.1. Mutaciones o polimorfismos en TLR1 35 5.3.3.2. Mutaciones o polimorfismos en TLR2 36 5.3.3.3. Mutaciones o polimorfismos en TLR4 37 5.3.3.4. Mutaciones o polimorfismos en NOD2 37 6. DISCUSIÓN 38 7. CONCLUSIONES 41 8. REFERENCIAS 42spa
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dc.format.mimetypeapplication/pdfspa
dc.language.isospaspa
dc.publisherUniversidad Colegio Mayor de Cundinamarcaspa
dc.rightsDerechos Reservados - Universidad Colegio Mayor de Cundinamarca, 2024spa
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/spa
dc.titleAsociación entre mutaciones genómicas y susceptibilidad al desarrollo de lepra: Revisión sistemática y metaanálisisspa
dc.typeTrabajo de grado - Pregradospa
dc.contributor.corporatenameUniversidad Colegio Mayor de Cundinamarcaspa
dc.description.degreelevelPregradospa
dc.description.degreenameBacteriólogo(a) y Laboratorista Clínicospa
dc.publisher.facultyFacultad de Ciencias de la Saludspa
dc.publisher.placeBogotá D.Cspa
dc.publisher.programBacteriología y Laboratorio Clínicospa
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dc.subject.proposalLepraspa
dc.subject.proposalMarcadores genéticosspa
dc.subject.proposalSusceptibilidadspa
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dc.type.coarversionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
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